The German letter 'q' is similar to English in that it's always followed by a 'u'. However, the German pronunciation of the 'qu' letter combination is very much different than in English; as it's pronounced as a 'kv' letter combination, which is an unfamiliar sound to English speakers.
The 'qu' letter combination could appear at the start or the middle of a word, but it never ends one.
|Letter combination 'qu' in initial position|
|Qualm - thick smoke||Quelle - source||Quittung - receipt|
|Quiz - quiz||quer - diagonally||Qualle - jellyfish|
|Letter combination 'qu' in medial position|
|Frequenz - frequency||adäquat - adequate||bequem - comfortable|
|Sequenz - sequence||Aquarium - aquarium||Liquidität - liquidity|
You might take sometime until you get used to the sound. Also spelling words containing the 'qu' combination might be a bit confusing at first.